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Because of the long elimination half-lives of the parent drug and its major active metabolite, changes in dose will not be fully reflected in plasma for several weeks, affecting both strategies for titration to final dose and withdrawal from treatment

Recent studies demonstrated that in chronic progressive SCZ, microglial reactivity and immune-oxidative pathway are elevated in early stages associated with age, accompanied by mitochondrial loss and cellular degeneration, whereas continuous schizophrenia shows consistently low microglial reactivity (Rajasekaran et al., 2015

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Am J Physiol-Cell Physiol 2010, 299:C497C505

Depending on its level of purity and how it is produced, water can have very different applications, ranging from preparing buffers for molecular biology to being used as Water for Injection (WFI) in pharmaceutical manufacturing