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FTD3 neurons exhibit decreased glycolytic activity and increased mitochondrial TCA turnover It is widely accepted that glucose hypometabolism is a pathological hallmark of several neurodegenerative disorders including FTD [9, 17]
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Thus, cellular concentrations are tightly regulated by various mechanisms to maintain a stable GSH:GSSG ratio and redox potential
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10.1038/nature14344 106 JiangY.HeY.LiuS.TaoY
