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Notably, FTMT knockout mice are viable and display no significant defects in systemic iron metabolism under baseline conditions 36 , but have been shown to be susceptible to oxidative or neurotoxic insults 37,38,39,40

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These properties underpin ALAs neuroprotective effects in 6-hydroxydopamine (6-OHDA)-induced Parkinsons disease mouse models, where it regulates iron metabolism and reduces oxidative stress [22]