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Compound Overview Class of Compound: Peptide Mechanism of Action: Epithalon upregulates telomerase activity and elongates telomeres, with the effect of delaying aging processes in reproductive and immune systems and increasing the longevity of test subjects Notable Studies: Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells AEDG Peptide (epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data Also Known As: Epitalon, 307297-39-8, Epithalone, UNII-O65P17785G, O65P17785G, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine acetic acid Research Applications: Anti-aging & longevity Sleep enhancement Disease prevention Risks: Injection site pain Lack of FDA approval Research concentrated in one group Chemical Structure What is Epithalon

TET1 specifically binds to target DNA through its CXXC domain, which uniquely interacts with unmethylated CpG dinucleotides, typically occurring at gene promoters or enhancer regions crucial for gene expression regulation (41, 42)

The background on the reconstituted ThioStar will increase slowly over time but the increase will not affect the assay results obtained

CRISPR-dCas9 epigenome editing platforms employ catalytically dead Cas9 fused to epigenetic effectors ( TET1 for active demethylation, DNMT3A for targeted methylation) without DNA breaks, enabling precise chromatin manipulation

The technology is currently one of the most active research areas, and has enormous potential for application in nanomedicine