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As shown in Figures 3(a,c,f) and S5(a,c,f), principal component analysis (PCA) indicated a distinct clustering of microbial taxa between the S-amlodipine-treated group and the control group, implying a substantial difference in the structure of the gut microbiota following S-amlodipine treatment
ROS can lead to NLRP3 activation through binding to thioredoxin-interacting protein (TXNIP) binding following thioredoxin oxidation (Zhou et al., 2011)
10.1038/ng.717 42 FridlenderZ
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