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RSL3 stimulation elevated C3, IL-1, and TNF- levels in mixed glial cultures, while the ferroptosis inhibitor liproxstatin-1 effectively attenuated RSL3-induced neurotoxicity, supporting a role for ferroptotic stress in promoting neurotoxic glial activation

Transl Res 164:4656

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In fact, during oxidative stress conditions, there is an increase in the release of many factors, such as nuclear factor kappa (NFk), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2), leading to the enhancement of nitrosative stress and consequently the damage of fatty acids and proteins at the membrane level, all underpinning chronic fatigue [21]

Ambadapadi,Interactions of cytosolic sulfotransferases with xenobiotics