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[1] [2] Neurological protection: Prompt B12 replacement prevents irreversible neurological damage in deficiency states, including subacute combined degeneration of the spinal cord

But if you are losing weight consistently at your current dose with manageable side effects, there is no reason to increase

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In summary, our data provide new insights into the effects of tesofensine on weight loss and the underlying neuronal mechanisms, suggesting that tesofensine may be an effective treatment for obesity and that it may be a valuable adjunct to other appetite suppressants to prevent body weight rebound