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The correct approach is to freeze only the lyophilized powder before reconstitution, never the reconstituted solution

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doi: 10.1111/jphp.13317

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In vitro angiogenesis (tube formation) assay The in vitro angiogenic activity of HUVECs (human umbilical vein endothelial cells) was determined by the Matrigel tube formation assay

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Int J Mol Sci 25:2360

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The crimp seal is applied at the end of the manufacturing process and provides visual verification that the vial has not been previously opened

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