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Previous studies have demonstrated that infertile men exhibit elevated levels of oxidative stress markers, including reactive oxygen species (ROS), lipid peroxidation products, and reduced antioxidant capacity in their semen and reproductive tissues

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Expansion of BMAT with caloric restriction can be blunted by overexpressing Wnt10b specifically in osteoblast lineage cells, likely by inhibiting the differentiation of skeletal progenitor cells into adipocytes (90)

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Nonetheless, two recently reported large RCTs showed that folic acid and zinc supplements (FAZST) or combination antioxidant treatment including Vitamin C, Vitamin E, folic acid, selenium, zinc, and l-carnitine (MOXI trial) did not improve clinical pregnancy or live birth rates when compared to placebo (Schisterman et al