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HungMHLeeJSMaCDiggsLPHeinrichSChangCWet alTumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

Proc Natl Acad Sci USA 1999;96:72205

Conclusion In the present study, we examined the effects of a reactive sulfur species, GSSSG, on proinflammatory cytokine expression in glial cells in vitro and on retinal inflammation in rodents using LPS-induced inflammation models

Though the mechanism for DMF function is still not fully understood, published reports support the therapeutic potential of DMF in oxidative stress regulation in alleviating SCD symptoms

Moreover, oxidative stress is frequently linked to inflammation, which may be reflected by increased indoleamine 2,3-dioxygenase 1 ( IDO1 ) activity, observed as an elevated plasma kynurenine/tryptophan ratio