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First, nanocarriers directly deliver ferroptosis modulators to molecular targets, depleting GSH via cystine disruption, inhibiting GPX4, or elevating labile iron pools to amplify lipid peroxidation
doi: 10.1038/nsmb.1474 120 XueBZYangZGWangXFShiH
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The levels of OC-STAMP, as well as indexes associated with ferroptosis and fibrosis, were assessed using Hematoxylin and eosin (HE), Masson, Sirius red staining, immunohistochemistry, and western blot analysis
In the group of retinas observed 2 wk after AAV2-CAG-hEDN1 injection, there was no significant change in the distribution or quantity of RGCs compared with the group of retinas injected with AAV2-CAG-stuffer as a control vector (Fig S2AD)
