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However, autophagy during prolonged stress can lead to cell death

73(2): 42937 Simmons RM, Webster AA, Kalra AB, et al

Punctal plugs, which use small collagen or silicone plugs to temporarily block the tear ducts, are effective in patients with severe ADDE, blocking tear drainage and increasing tear retention on the ocular surface [20]

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Concerning LC-induced effect on the seminiferous tubule's diameter, it could be said that LC's protective and anti-oxidant role against free radicals reduces the oxidative stress, accelerating spermatogenesis cells' differentiation and increasing sperm release from the seminiferous tubule luminal surface (20)