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Complement activation leads to interaction with antigens, providing a potent signal through binding to B cell receptors, which lowers the activation threshold and enhances the antibody response, while activating macrophages and cytokines, such as interleukins (IL)-8 and IL-1 [103]

For example, in the 2020 case study , the woman developed symptoms after consuming a total of 12 milligrams of vitamin B12, which is exponentially more than the recommended daily intake (RDI)

The most common types of these anemias are megaloblastic anemia or iron deficiency anemia caused by folate or B12 deficiency

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