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However, although A with 42 amino acid residues (A (1-42) ) is available in low quantities, it is highly prone to aggregation and readily self-assembles to form a heterogenous mixture of oligomers and PF subsequently deposited as fibrils in senile plaques [160, 161]

Due to this, in the past few decades, several investigators have shown a strong research interest in understanding the molecular mechanisms of action of curcumin and its additional beneficial effects in preventing various complications

Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT (eds.)

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63 The expression of MTHFD2 is closely related to the response of the folate antagonist methotrexate (MTX) and the thymidylate synthase inhibitor pemetrexed