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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

10.1016/j.jmb.2019.07.001 119 NussbaumR

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In addition to the 28-kDa cleavage product of the BDNF precursor, the 14-kDa mature BDNF is generated after cleavage of proBDNF by furin-like protein convertases PACE4, PC1, or PC5 (Mowla et al

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