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Growth hormone stimulates hepatic IGF-1 production by binding to growth hormone receptors on liver cells, triggering intracellular signaling through the JAK2/STAT5 pathway that upregulates IGF-1 gene expression

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GLP-1 Peptide Medications GLP-1 peptides -- such as semaglutide and tirzepatide -- may be a more clinically validated option for patients whose primary goal is meaningful weight loss, and these are addressed in separate articles in this Peptide Series