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Description
The NPs were responsive to pH alterations, CS/PGA-DTPA NPs swelled with increasing pH and disintegrated above pH 7.0

Meaning your gut wall isnt as strong as it once was

D., Bernard, L

Hence, in general, the stability of formyl- and/or oxidized forms is much higher than that of methyl- and/or reduced ones, and the acidic environment accelerates the thermal decomposition 66,106,234,346,363,364,365,366,367,368,369,370,371,372,373,374

L.CattabeniF.et al (2011)