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Each disorder presents with its own hallmark abnormalities in spine dynamics, which further corroborates the idea that spines are structural underpinnings for proper cognitive functioning

doi: 10.1016/j.it.2020.11.001 67 KozowskaAMackiewiczJMackiewiczA

Altogether, this evidence positions the MTHFR-SAM-DNMT axis at the core of SLE immunoepigenetics: Metabolic constraint yields methylation defects that hardwire the interferon-skewed, proinflammatory state