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In conclusion, astrocytes capacity to clear toxic damaged proteins is critical to preserve neuronal function and their dysfunction contributes to the neurodegeneration observed in a DJ1 loss-of-function PD model

10.1016/S0140-6736(16)00578-X 193 MakabeH.KojikaM.TakahashiG.MatsumotoN.ShibataS.SuzukiY.et al (2012)

Furthermore, microinjections of leptin in rodents, into the ventromedial hypothalamus (VMH) 21 and the arcuate nucleus (ARC) 22 can decrease food intake massively, suggesting that leptins actions are mediated mainly by the hypothalamus

Abeta-amyloid and Tau Imaging in Dementia