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Prolotherapy creates a mild, controlled inflammation that stimulates the body to lay down collagen with the formation of new tendon, ligament, and cartilage, resulting in a strengthening of the weakened structure

Wotzka SY, Kreuzer M, Maier L, Arnoldini M, Nguyen BD, Brachmann AO, Berthold DL, Znd M, Hausmann A, Bakkeren E, et al

However, curcumin faces inherent limitations including poor bioavailability and inefficient BBB penetration, which hinder its clinical translation

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These effects were observed across multiple organ systems and disease models, highlighting its broad therapeutic potential