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These structures occupy a uniquely powerful position in biology: they are too small to be classified as full proteins, yet too biologically active to be dismissed as simple building blocks

Because of this, energy levels are constantly being broken down through cellular metabolism so they can be reformed to meet the oxygen demand

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To explain this, it was proposed that -Arrs regulate the parameters of a second wave of signal transduction (i.e., ERK activation) through receptor desensitization/internalization and scaffolding of signaling components, rather than through directing activating ERK themselves (Gutkind and Kostenis, 2018)