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Clinical trials conducted at the Serbsky Center for Social and Forensic Psychiatry (N=62) demonstrated a 2-fold reduction in Hamilton Anxiety Rating Scale (HAM-A) scores compared to placebo over a 14-day treatment period

2011;25(1_MeetingAbstracts):997.1

Despite the absence of a prolonged anorectic effect, Cagrilintide produced a sustained and significant reduction in body weight in WT mice by 3.4 g after 21 days, while no such effect was observed in KO animals

Fibrosis is staged F0 (none) through F4 (cirrhosis), and clinical trials typically enroll patients with F2F3 (moderate to advanced) fibrosis because that is where the therapeutic need and the regulatory bar is highest