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During cuprizone-induced demyelination, the complement proteins C3a and C5a increase the numbers of microglia present at the site of injury and might stimulate microglia to express pro-inflammatory cytokines [218]
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But the value equation becomes more complex when you factor in efficacy and treatment duration
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Further investigations into the mechanism of action of TRZ at the spinal level are ongoing and further clinical studies could be useful to assess the effect of even lower doses of TRZ for treating neuropathic pain
