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Many oxidative electrophilic PTMs (e.g., cysteine oxidation at Cys151, Cys273 and Cys288) promote Nrf2 activation, leading to antioxidant gene induction, reduced ROS burden and limited TXNIP released from TRX thereby suppressing NLRP3 assembly

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The initial report of those data will not disappear

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62 This approach could be particularly useful in cases that a large cartilage surface needs to be replaced, and there are signs of joint inflammation

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