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Harry Eagle who, by investigating the nutritional requirements for survival and growth of mammalian cells in in vitro conditions, showed that the classified non-essential amino acidcysteine (CySH), is not only essential for proliferation of cells in culture, but its absence inevitably leads to very specific type of cell death 12,13,14

These findings are supported by existing research and indicate that effective proteins play a crucial role in the cytotoxic effects of isolated Lactobacillus strains

J Biol Chem 287(12):89208931

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Such a Se-utilization hierarchy amongst selenoproteins and body compartments is related to the sophisticated regulation of selenoprotein expression (Papp et al., 2007
