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doi: 10.1038/s41401-021-00830-1 99 FuTWangSLiuJCaiELiHLiPet al

10.3389/fnagi.2016.00308 Front

High IGF-1 Possible increased cancer risk, accelerated cell proliferation without adequate repair balance

Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies

Targeting IGF-1R preferentially decreases ALDH + and CD44 + /CD24 CSC populations, suggesting that the IGF pathway sustains the CSC niche [96,98]
