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Glucuronide conjugation of aniline (which is used to make polyurethane, pharmaceuticals, and industrial chemicals) (Image Source: NLM) Sulfate Conjugation Sulfate conjugation is another important Phase II reaction that occurs with many xenobiotics

Thalamocortical projections then relay this information to the primary and secondary somatosensory cortices, enabling the precise localization, intensity discrimination, and temporal analysis of the painful stimulus

In contrast, ketamine and phencyclidine, have a greater inhibitory effect on synaptic NMDA receptor/channels

"In fact, the big studies coming out are telling us that [after taking one of these medications] for about a year to a year-and-a-half, people are achieving about 15% to 20% weight loss." Additionally, patients are seeing improved liver function and lower rates of stroke as well as kidney and heart disease