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More recently, tofersen (QALSODY ), an antisense oligonucleotide targeting mutant SOD1 , has shown potential in reducing NfL levels and slowing functional decline, though concerns remain regarding inflammatory side effects and the failure of initial phase III trials [7678]

Nrf2 can positively promote the synthesis of GSH and ferritin by upregulating relative genes like xCT, GCLC, and GCLM [80, 81]

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10.1111/bph.13616 31 CortiA.DominiciS.PiaggiS.BelcastroE.ChiuM.TaurinoG.et al (2019)

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