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The Cas9/sgRNA ribonucleoprotein complex, while the most responsive mode of action, has a low off-target rate and low toxicity, but the large size of the complex complicates delivery
Reactive astrocytes might be also involved the neuroinflammation and the BBB dysfunction, as observed in multiple sclerosis and experimental autoimmune encephalomyelitis [117, 118]
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doi: 10.1016/j.redox.2025.103590
