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FDA-approved peptides (GLP-1 agonists, PT-141) have established safety data

Polyamine metabolism starts with the basic, non-protein genic -amino acid L-ornithine

For all experiments mice were kept at 2425 C, 40% humidity, group-housed in standard cages under a 12 h light/dark cycle, and fed ad libitum with standard animal chow and water

These findings suggest that targeting Sphk1 could offer a promising approach for preventing and treating ICH-related neurodegeneration

Unnikrishnan G, Joy A, Megha M, Kolanthai E, Senthilkumar M
