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At this time, flumazenil is not Food and Drug Administration-approved nor guideline-recommended (AASLD 2014) for the treatment of HE, though it is mentioned as possible therapy in select cases pending further study

Furthermore, pigmented lesions in MGLSc can portray concerning morphological features even when benign

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In addition to melanocytes, several studies proved significant biochemical alterations and increased production of ROS in other skin cell types, particularly keratinocytes and fibroblasts [74,180]