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Autophagy 4 , 351353 (2008)
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The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development
They counteract the inability to initiate movement and catalepsy (muscular rigidity and fixed posture regardless of external stimuli), which in turn results in significantly reduced dopaminergic cell activity that is involved in the direct pathway of movement
In a study in diet-treated diabetic patients, even a single mixed meal of 450 Calories caused immediate and significant impairment in endothelial function, a key early step in the development of atherosclerosis
