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Semaglutide, on the other hand, is a GLP-1 receptor agonist originally designed to manage type 2 diabetes
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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown
The absence of IGF-1 elevation and glucose metabolism impairment represents a significant safety advantage for long-term applications
