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Oxidative stress and vascular damage are considered two major cellular factors that lead to alterations in the TM

We analyze 290 approvals for which demographic data are reported in the FDA Snapshots between 2014 and 2021 (as of May 1, 2021)

doi: 10.1210/clinem/dgaa882 199 HageCSalvatoriR

Patient-derived xenograft (PDX) cells that survived after treatment with various anticancer drugs showed lower risk scores (RS), lower KRAS expression levels, lower activation states of the RAS-MAPK signaling pathway, and significantly different expressions of ion channel transport genes, which may be related to drug resistance mechanisms (Kim et al., 2015)

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