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There is no need to reduce the particle size of freely water soluble drugs, e.g

However, these studies excluded patients with a history of major depressive disorder and suicidal ideation, limiting the generalizability of their findings

The injections sit in the muscle tissue as kind of a reservoir and slowly leak out over time into the blood, explains Joshua Miller, Ph.D., a B12 researcher, and professor and chair in the Department of Nutritional Sciences at the School of Environmental and Biological Sciences at Rutgers University