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Description
Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

The advanced protocol should only be implemented after successful tolerance of lower doses and under appropriate medical supervision

Retrieved 28 September 2011.

Discard after 28 days

Digestive system problems Nausea Mild diarrhea Cramping or gas 3
