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Notably, these studies helped to infer that there exists a close relation between GSH and Pro, and that exogenous and/or synthesized/ stress-caused elevated Pro can protect plants against the metal and salinity-stress impacts by safe-guarding the activity of previous enzymatic components, improving the cellular redox environment via decreasing H 2 O 2 level and maintaining an increased level of reduced GSH and GSSG/GSH ratio

Abbreviations APACHE: Acute physiology and chronic health evaluation CRP: C-reactive protein Glu: Glutamic acid GOT or AST: Glutamic oxaloacetic transaminase or aspartate transaminase GPT or ALT: Glutamic pyruvic transaminase or alanine transaminase GPX: Glutathione peroxidase GPX1: Cellular glutathione peroxidase GSH: Glutathione ICU: Intensive care unit PCT: Procalcitonin PyroGlu: Pyroglutamic acid SOFA: Sequential organ failure assessment References Gerlach H, Keh D

Hepatocyte growth factor is also expressed in neuro-microvascular endothelial cells (Rosen et al., 1996), and an association between growth factors and increased angiogenesis in ischemic injuries is reported in literature

Pikal MJ, Rigsbee D, Roy ML, et al

doi: 10.1016/j.redox.2018.101087 78 ZhengM.slundF.StorzG