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In order to reduce the side effects, p-dodecylaminophenol (p-DDAP) was further designed, and it has been demonstrated to be effective against a wide range of cancers [200]

Based on these and our data we propose that upregulated ether lipid synthesis in non-NE SCLC feeds into the ferroptosis vulnerable membrane lipid pool generated and re-generated by ACSL4 and LPCAT3 creating a ferroptosis-prone membrane lipid pool through the addition of ether-linked PUFAs

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SAE, which includes critical or life-threatening illness or death, will be documented from the time of enrolment throughout the study period

For instance, quercetin-3-glucoside from apples and onions reduces oxidative stress similar to metformin, while epigallocatechin-3-O-gallate (EGCG) found in green tea increases energy expenditure and decreases inflammation and oxidative stress by inhibiting the NF-kB pathway [68]