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These findings from animal models suggest that astrocytic lactate release may involve multiple pathways beyond monocarboxylate transporters, allowing adaptive responses to neuronal energy demands and pathological stress

Muramatsu, H

In mice treated with amoxicillin or ciprofloxacin, depletion of Lactobacillus reuteri (Firmicutes) led to reduced brain and serum GABA, downregulation of GABA-A receptors, and diminished 5-HT and DA, neurochemical changes that coincided with anxiety- and depression-like behaviors (Bibi et al., 2025)

Accordingly, microbiota-targeted interventions have emerged as promising approaches to restore immune homeostasis and improve clinical outcomes

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