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Further chemical proteomics investigations have demonstrated that A16 specifically targets GPX4 under both in situ and in vivo conditions, inducing ferroptosis

This study was conducted with reference to a previous investigation on the reproductive toxicity of PS-MPs in male mice, in which the administered dose of PS-MPs was 1 mg/day (equivalent to 33.340 mg/kg/day for mice weighing 2530 g) [40]

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Consistent with this view, Ham and colleagues reported that deep WM lesions are closely associated with decreased cortical thickness, perhaps leading to the declines in executive function that are evident in PD (Ham et al., 2015)

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