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(2010) High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats

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Whereas GLP-1 monotherapy slightly reduced plasma aspartate aminotransferase (AST) levels compared with those in MK-801-treated mice, GLP-1MK-801 treatment did not affect plasma AST or alanine transaminase (ALT) levels (Extended Data Fig

The side effects we see in clinic are generally mild: transient injection site reaction, occasional mild nausea if starting at too high a dose, infrequent headache or lightheadedness in the first week