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Emergence of autoreactive IgG3 may cause the acute onset of the disease [162], which on account of the potent immune-activating properties of IgG3 points to immune activation being a pathological driver

Joint hypermobility and hypotonia may be the reason for delayed motor development, delayed walking or frequent stumbling as well as mild motor disturbance (clumsiness) in children

Trans Psychiatry

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Therefore, further large-scale and better-standardized clinical studies with stratified populations are urgently needed to provide more robust data on the association between altered gut microbial features and schizophrenia