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Cell culture studies In laboratory studies using 3T3-L1 adipocytes, a commonly used fat cell line, researchers found that 5-amino-1mq significantly reduced intracellular levels of 1-methylnicotinamide, confirming that it was successfully inhibiting NNMT

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[DOI] [PMC free article] [PubMed] [Google Scholar] 422

These metabolic improvements appeared to start before significant weight loss was visible, suggesting that disrupting white fat vasculature has metabolic effects beyond simple fat reduction
