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Strikingly, selective deletion of EAAT2 in spinal cord astrocytes is sufficient to induce motor neuron degeneration and impairs motor learning and coordination in mice [391]

Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway

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Different immune cells mediate mechanical pain hypersensitivity in male and female mice