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Letter by Violi and Pignatelli regarding article, "Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study"

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As a critical regulator of oxidative stress and metabolic adaptation, Nrf2 mediates the benefits of these interventions

The cystine is added separately at final 0, 5 or 48.3 mg/L (equivalent to 0, 30, and 292 M), depending on experiments

Category 2: FDA-approved for specific conditions, prescribed off-label within longevity discussions