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Thus, the feedforward loop connecting P62 and Nrf2 is destroyed, the antioxidant capacity of testis is reduced, and the oxidative stress of testis is further aggravated, forming a vicious circulation (Tian et al
[DOI] [PubMed] [Google Scholar] 130.Kemahli E., Uyeturk U., Cetinkaya A., Erimsah S., Uyeturk U., Gucuk A

[DOI] [PubMed] [Google Scholar] 354.Chang JC, Chang HS, Wu YC, Cheng WL, Lin TT, Chang HJ, et al

Then, Lepr db/+ - Il1r1 /+ were crossed together to obtain Lepr db/db - Il1r1 / mice