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10.1016/j.jpba.2021.114040 14 FrudeE.McKayF

Shorb knew that the same liver extract was used to treat pernicious anemia (her father-in-law had died from the disease), and concluded that LLD could be developed as an assay method to identify the active compound

Because regulatory approval requires: robust human clinical trials demonstrated efficacy established long-term safety These data are currently lacking

The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements