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Not knowing if it is safe and being unsafe are not necessarily the same, says Carmella Britt, DVM, veterinarian at Care First Animal Hospital in Raleigh, NC, diplomate of the American College of Veterinary Sports Medicine and Rehabilitation

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Following distribution into tissues, methylene blue is rapidly reduced to leukomethylene blue (leucomethylthioninium chloride)

Activities that may increase MMA (and worsen B12 status) include: Vegan/vegetarian diets: Plant-based diets naturally contain little or no B12, potentially leading to higher MMA if not supplemented

In most cases, side effects diminish after a few weeks as the body adjusts
