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& Hamza, A

The MTHFR enzyme is responsible for converting folate into its active form, 5-methyltetrahydrofolate

Through metagenomic sequencing and in vitro coculture experiments of peripheral blood mononuclear cells (PBMCs), it was verified that butyrate can selectively expand peripheral blood Tregs in RA patients, inhibit the activation of conventional T cells (Tconvs), downregulate the production of anti-citrullinated peptide antibodies (ACPA), and reduce cartilage and bone tissue damage

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Reconstitution should be performed in a laminar flow hood or clean environment to prevent contamination