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Toward precision medicine in glioblastoma: the promise and the challenges

P., Gunasekara, D

Additional contributions come from enzymes such as xanthine oxidase and cyclooxygenases, as well as endoplasmic reticulum stress and unfolded protein response activation, which further exacerbate oxidative stress through disrupted calcium homeostasis and oxidative signaling pathways (Fig

Concurrently, sodium urate crystals activate the bypass pathway and lectin pathway of the complement system, leading to the production of C5a, C3a, and other allergic toxins, as well as C3b and other opsonin fragments

These data support a role for GSH as an upstream regulator of pyroptosis by coupling metabolic redox status to inflammasome activation